Crizotinib hydrochloride_1415560-69-8_DataSheet_MedChemExpress
Product Data Sheet
Product Name:
CAS No.:
Cat. No.:
MWt:
Formula:
Purity :Crizotinib hydrochloride1415560-69-8HY-50878A486.80C21H23Cl3FN5O>98%
Solubility:DMSO
Mechanisms: Pathways:Protein Tyrosine Kinase/RTK; Target:c-Met/HGFR
Pathways:Protein Tyrosine Kinase/RTK; Target:ALK
Pathways:Protein Tyrosine Kinase/RTK; Target:EML
Pathways:Protein Tyrosine Kinase/RTK; Target:Ros1
Biological Activity:
Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell
proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment ofanaplastic large-cell lymphoma.
References:
[1]. Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB, Riely GJ, Solomon B,Ou SH, Kim DW, Salgia R, Fidias P, Engelman JA, Gandhi L, J?nne PA, Costa DB, Shapiro GI,Lorusso P, Ruffner K, Stephenson P, Tang Y, Wilner K, Clark JW, Shaw AT.Activity and safety ofcrizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase http://www.mianfeiwendang.comncet Oncol. 2012 Sep 3.
[2]. Sparidans RW, Tang SC, Nguyen LN, Schinkel AH, Schellens JH, Beijnen JH.Liquid
chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse
plasma.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Sep 15;905:150-4. Epub 2012 Aug21.
[3]. Crystal AS, Shaw AT.Variants on a Theme: A Biomarker of Crizotinib Response in ALK-PositiveNon-Small Cell Lung Cancer?Clin Cancer Res. 2012 Sep 1;18(17):4479-81. Epub 2012 Aug 21.
[4...
Caution: Not fully tested. For research purposes only
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