Crizotinib hydrochloride_1415560-69-8_DataSheet_MedChemExpress

Product Data Sheet

Crizotinib hydrochloride_1415560-69-8_DataSheet_MedChemExpress

Crizotinib hydrochloride_1415560-69-8_DataSheet_MedChemExpress

Product Name:

CAS No.:

Cat. No.:

MWt:

Formula:

Purity :Crizotinib hydrochloride1415560-69-8HY-50878A486.80C21H23Cl3FN5O>98%

Solubility:DMSO

Mechanisms: Pathways:Protein Tyrosine Kinase/RTK; Target:c-Met/HGFR

Pathways:Protein Tyrosine Kinase/RTK; Target:ALK

Pathways:Protein Tyrosine Kinase/RTK; Target:EML

Pathways:Protein Tyrosine Kinase/RTK; Target:Ros1

Biological Activity:

Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell

proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment ofanaplastic large-cell lymphoma.

References:

[1]. Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB, Riely GJ, Solomon B,Ou SH, Kim DW, Salgia R, Fidias P, Engelman JA, Gandhi L, J?nne PA, Costa DB, Shapiro GI,Lorusso P, Ruffner K, Stephenson P, Tang Y, Wilner K, Clark JW, Shaw AT.Activity and safety ofcrizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase http://www.mianfeiwendang.comncet Oncol. 2012 Sep 3.

[2]. Sparidans RW, Tang SC, Nguyen LN, Schinkel AH, Schellens JH, Beijnen JH.Liquid

chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse

plasma.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Sep 15;905:150-4. Epub 2012 Aug21.

[3]. Crystal AS, Shaw AT.Variants on a Theme: A Biomarker of Crizotinib Response in ALK-PositiveNon-Small Cell Lung Cancer?Clin Cancer Res. 2012 Sep 1;18(17):4479-81. Epub 2012 Aug 21.

[4...

Caution: Not fully tested. For research purposes only

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